Deoxyribonucleic acid (; DNA) is a molecule that encodes the genetic instructions used in the development and functioning of all known living organisms and many viruses. DNA is a nucleic acid; alongside proteins and carbohydrates, nucleic acids compose the three major macromolecules essential for all known forms of life. Most DNA molecules consist of two biopolymer strands coiled around each other to form a double helix. The two DNA strands are known as polynucleotides since they are composed of simpler units called nucleotides. Each nucleotide is composed of a nitrogen-containing nucleobase—either guanine (G), adenine (A), thymine (T), or cytosine (C)—as well as a monosaccharide sugar called deoxyribose and a phosphate group. The nucleotides are joined to one another in a chain by covalent bonds between the sugar of one nucleotide and the phosphate of the next, resulting in an alternating sugar-phosphate backbone. According to base pairing rules (A with T and C with G), hydrogen bonds bind the nitrogenous bases of the two separate polynucleotide strands to make double-stranded DNA. DNA is well-suited for biological information storage. The DNA backbone is resistant to cleavage, and both strands of the double-stranded structure store the same biological information. Biological information is replicated as the two strands are separated. A significant portion of DNA (more than 98% for humans) is non-coding, meaning that these sections do not serve as patterns for protein sequences. The two strands of DNA run in opposite directions to each other and are therefore anti-parallel. Attached to each sugar is one of four types of nucleobases (informally, bases). It is the sequence of these four nucleobases along the backbone that encodes biological information. Under the genetic code, RNA strands are translated to specify the sequence of amino acids within proteins. These RNA strands are initially created using DNA strands as a template in a process called transcription. Within cells, DNA is organized into long structures called chromosomes. During cell division these chromosomes are duplicated in the process of DNA replication, providing each cell its own complete set of chromosomes. Eukaryotic organisms (animals, plants, fungi, and protists) store most of their DNA inside the cell nucleus and some of their DNA in organelles, such as mitochondria or chloroplasts. In contrast, prokaryotes (bacteria and archaea) store their DNA only in the cytoplasm. Within the chromosomes, chromatin proteins such as histones compact and organize DNA. These compact structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed. Scientists use DNA as a molecular tool to explore physical laws and theories, such as the ergodic theorem and the theory of elasticity. The unique material properties of DNA have made it an attractive molecule for material scientists and engineers interested in micro- and nano-fabrication. Among notable advances in this field are DNA origami and DNA-based hybrid materials. The obsolete synonym “desoxyribonucleic acid” may occasionally be encountered, for example, in pre-1953 genetics.
About the Author: Matt Artz
Matt Artz is a business and design anthropologist, consultant, author, speaker, and creator. He writes, speaks, and consults in user experience, product management, and business strategy. He creates products, podcasts, music, and visual art. Matt is the Head of Product and Experience for Cloudshadow Consulting and Artmatcher. He is also the Founder of Anthro to UX, Azimuth Labs, and Biomega Technologies. He earned a Masters of Science in Applied Anthropology from the University of North Texas in 2018, an MBA in Finance and Management Information Systems from Marywood University in 2008, a BS in Biotechnology from Marywood University in 2008, and a BBA in Computer Information Systems from Marywood University in 2006. As an anthropologist and consultant, he is known for his research interests and work in business anthropology, design anthropology, consumer genetics, user experience, product management, big data, sensemaking, and algorithmic bias. Matt is also the creator of the Anthropology in Business podcast and Anthro to UX podcast where he discusses the application of anthropology to business and UX. He has been featured by TEDx, SXSW, Anthropology News, MedPage Today, Kevin MD Technically, UX Planet, Towards Data Science, Product Coalition, and the University of North Texas. You can follow Matt on LinkedIn, Twitter, Instagram, Spotify, and Google Scholar.