Affymetrix, Inc. is an American company that manufactures DNA microarrays; it is based in Santa Clara, California, United States. The company was founded by Dr. Stephen Fodor in 1992. It began as a unit in Affymax N.V. in 1991 by Fodor’s group, which had in the late 1980s developed methods for fabricating DNA microarrays, called “GeneChip” according to the Affymetrix trademark, using semiconductor manufacturing techniques. The company’s first product, an HIV genotyping GeneChip, was introduced in 1994 and the company went public in 1996. As a result of its pioneering work and the ensuing popularity of microarray products, Affymetrix derives significant benefit from its patent portfolio in this area. Acquisitions have included Genetic MicroSystems for slide-based microarrays and scanners, Neomorphic for bioinformatics, ParAllele Bioscience for custom SNP genotyping, USB/Anatrace for biochemical reagents, eBioscience for flow cytometry, and Panomics and True Materials to expand its offering of low to mid-plex applications. In 2000, Perlegen Sciences spun out from Affymetrix to focus on wafer-scale genomics for massive data creation and collection required for characterizing population variance of genomic markers and expression for the drug discovery process.